Conference proceeding
Nanodiamond Reinforced PLLA Nanocomposites for Bone Tissue Engineering
ASME 2012 International Manufacturing Science and Engineering Conference, pp 885-889
04 Jun 2012
Abstract
Nanodiamond (ND) is an attractive nanomaterial for reinforcement of biopolymers due to the ND’s superior mechanical and chemical properties, and low biotoxicity. A novel composite material has been produced for bone scaffolds utilizing the biodegradable polymer poly(L-lactic acid) (PLLA) and octadecylamine-functionalized nanodiamond (ND-ODA). Composites were prepared by admixing to a PLLA/chloroform solution chloroform suspension of ND-ODA in concentration range of 0–10% (w/w). The dispersion of ND-ODA evaluated by transmission electron microscopy (TEM) shows uniform distribution of ND-ODA in PLLA matrix. The composites were characterized by differential scanning calorimetry (DSC). DSC analysis of the composites showed no significant thermal behavior changes with the addition of ND-ODA into the polymer. Biomineralization test shows that ND-ODA can enhance the mineral deposition on scaffolds. Improved mechanical properties and good biocompatibility with enhanced biomineralization combined suggest that ND-ODA/PLLA might have potential applications for bone tissue engineering.
Metrics
8 Record Views
Details
- Title
- Nanodiamond Reinforced PLLA Nanocomposites for Bone Tissue Engineering
- Creators
- Qingwei Zhang - Drexel University, Philadelphia, PAYury Gogotsi - Drexel University, Philadelphia, PAPeter I Lelkes - Drexel University, Philadelphia, PAJack G Zhou - Drexel University, Philadelphia, PA
- Publication Details
- ASME 2012 International Manufacturing Science and Engineering Conference, pp 885-889
- Conference
- ASME 2012 International Manufacturing Science and Engineering Conference, 40th (Notre Dame, Indiana, United States, 04 Jun 2012–08 Jun 2012)
- Publisher
- American Society of Mechanical Engineers
- Number of pages
- 1
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- Materials Science and Engineering; Mechanical Engineering and Mechanics
- Scopus ID
- 2-s2.0-84883070580
- Other Identifier
- 991014970033604721