Conference proceeding
Nanostructured porous silicon scaffolds for improved biocompatibility of thin film microelectrodes
Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439), v 4, pp 3698-3699 Vol.4
2003
Abstract
The promise of multichannel thin film microelectrodes for closed-loop neural prosthetic control has been hindered by the inability of these electrodes to record for long periods of time. Recently, we have shown that thin film electrodes produced using a ceramic substrate and insulation (CBMSE arrays) can record single neuron action potentials for three months in the rat, which is comparable to microwire electrodes. To enhance their biocompatibility and increase the recording time, we suggest that a porous, biocompatible surface modification of the electrode can be used to anchor the electrode to the neural tissue and thereby, reduce tissue damage creating during long-term implantation of the electrode. We have optimized the process parameters for producing biocompatible porous silicon nanostructures. We have modified the surface of our microelectrodes with nanostructured porous silicon. The porous silicon (PS) layers are up to 50 /spl mu/m thick with porosities in the range of 10 to 75%. This porous silicon layer has been successfully attached to our thin film ceramic electrodes.
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Details
- Title
- Nanostructured porous silicon scaffolds for improved biocompatibility of thin film microelectrodes
- Creators
- K.A Moxon - Drexel UniversityN.M Kalkhoran
- Publication Details
- Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439), v 4, pp 3698-3699 Vol.4
- Publisher
- IEEE
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000189395300967
- Other Identifier
- 991019168879904721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Computer Science, Interdisciplinary Applications
- Engineering, Biomedical
- Medicine, Research & Experimental
- Neurosciences
- Radiology, Nuclear Medicine & Medical Imaging