Conference proceeding
New Biomimetic Aggrecan for Treatment of Intervertebral Disc Degeneration
2012 38TH ANNUAL NORTHEAST BIOENGINEERING CONFERENCE (NEBEC)
Annual IEEE Northeast Bioengineering Conference
01 Jan 2012
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Lower back pain resulting from intervertebral disc degeneration is one of the leading musculoskeletal disorders confronting our health system. Disc degeneration is accompanied by a decrease in aggrecan content in the nucleus pulposus. A possible approach to mechanically stabilizing the disc early in the degenerative cascade is by increasing the concentration of aggrecan in the nucleus to normal level thereby increasing hydration and intradiscal pressure. Treatment with natural aggrecan, however, is cost prohibitive. Here we report synthesis and characterization of an enzymatically-resistant, biomimetic aggrecan consisting of a synthetic polymer core with covalently attached chondroitin sulfate bristles. Our novel biomimetic aggrecan mimics the structure and osmotic properties of natural aggrecan and is cytocompatible.
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Details
- Title
- New Biomimetic Aggrecan for Treatment of Intervertebral Disc Degeneration
- Creators
- D. Madende - Drexel Univ, 3141Chestnut St, Philadelphia, PA 19104 USAK. Prudnikova - Drexel UniversityS. Lightfoot - Drexel UniversityE. Vresilovic - Penn State Univ, University Pk, PA 16802 USAM. Marcolongo - Drexel Univ, 3141Chestnut St, Philadelphia, PA 19104 USAIEEE
- Publication Details
- 2012 38TH ANNUAL NORTHEAST BIOENGINEERING CONFERENCE (NEBEC)
- Series
- Annual IEEE Northeast Bioengineering Conference
- Publisher
- IEEE
- Number of pages
- 2
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- Institute for Women's Health and Leadership; Materials Science and Engineering
- Identifiers
- 991019170457004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Engineering, Electrical & Electronic