Conference proceeding
POROUS MEDIA TUMOR MODEL FOR LIGHT PENETRATION AND OXYGEN DIFFUSION DURING PHOTODYNAMIC THERAPY
PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION 2008, VOL 2, v 2, pp 505-509
01 Jan 2009
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Photodynamic therapy (PDT) is an FDA approved, effective, and minimally invasive cancer treatment modality with few side effects. PDT requires three major components; photosensitizing agent, activation light, and molecular oxygen. Optimization of PDT for an individual patient requires good therapeutic selectivity and high efficacy, where the design of such an effective protocol is based on the understanding of the interaction of key therapeutic components with tumor tissue. Tumor models expressive of changes during the growth of tumor along with the behavior of PDT components facilitate the above requirement. In this study we have developed a mathematical model considering tumor as a porous medium of solid of and liquid that enables to express characteristics of a growing tumor. The characteristic lengths and the volumes that can be changed in the model represent the dynamic changes during the growth of the tumor. An energy based light transport model is superimposed with the porous media model to yield an analytical equation of light penetration in turbid media. In addition a molecular diffusion model combined with the porous media tumor model provides a second analytical equation yielding molecular oxygen diffusion during PDT. Experimentally available physiological and photophysical data are used to obtain the results from the developed models. The commonly used wavelength for PDT, 635nm and corresponding photophsical parameters for a healthy tissue are used for the calculations. The modeling results reveal an exponential decay of optical power along the direction of light penetration and the characteristic changes in oxygen diffusion during PDT. Further observations include the time dependent changes in photosensitizer photobleaching and the corresponding increase in oxygen diffusion length. The modeling results in both cases show a promising accordance with the available experimental results in literature. The model calculations also reveal the effect of light penetration on oxygen diffusion in PDT milieu adding to the expression of its usefulness.
Metrics
12 Record Views
Details
- Title
- POROUS MEDIA TUMOR MODEL FOR LIGHT PENETRATION AND OXYGEN DIFFUSION DURING PHOTODYNAMIC THERAPY
- Creators
- A. Premasiri - Southern Methodist UniversityA. Rosen - Drexel UniversityG. Happawana - California State University, FresnoASME
- Publication Details
- PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION 2008, VOL 2, v 2, pp 505-509
- Conference
- ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION 2008
- Publisher
- Amer Soc Mechanical Engineers
- Number of pages
- 5
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- Pathology (and Laboratory Medicine)
- Web of Science ID
- WOS:000265911300078
- Scopus ID
- 2-s2.0-70049117339
- Other Identifier
- 991019173859404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biotechnology & Applied Microbiology
- Engineering, Biomedical
- Engineering, Mechanical