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Q-dots as probes for dynamic observation of intracellular pathways
Conference proceeding

Q-dots as probes for dynamic observation of intracellular pathways

E Papazoglou, B Edrissi, A Rezvan and K Pourrezaei
IEEE 30th Annual Northeast Bioengineering Conference, 2004. Proceedings of the, pp 231-232
2004

Abstract

Biomedical optical imaging Cells (biology) Chemicals Fluorescence Nanobioscience Nanocrystals Nanoparticles Optical materials Probes Quantum dots
The interactions of semiconductor nanoparticles, known as Q-dots, with normal and cancerous cell lines were studied in order to develop a model system for the interactions of nanoparticles with cells. The main advantage of Q-dots over traditional chemical dyes is a bright fluorescence with prolonged photo stability. The most efficient method for non-invasive introduction of Q-dots into cells was determined to be culturing cells on plates already coated with collagen and Q-dots. Among the parameters investigated were the difference between cell lines, types of Q-dots used, and Q-dot functionalization. Live/dead assay was also carried to assess the viability of cells after being in contact with Q-dots for different time periods.

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Web of Science research areas
Engineering, Biomedical
Instruments & Instrumentation
Materials Science, Biomaterials
Radiology, Nuclear Medicine & Medical Imaging
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