Conference proceeding
Sensory gating in a computer model of the hippocampus
MEMORY AND EMOTION, v 12
01 Jan 2002
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A computational model of the CA3 hippocampal network was used to simulate two sensory processing deficits associated with schizophrenia: 1) a reduction in the absolute amplitude of the P50 auditory evoked potential and 2) a loss P50 auditory sensory gating. The model included recurrent activity between 600 CA3 pyramidal cells and 60 CA3 interneurons and simulated the response of the CA3 region of hippocampus; to auditory click stimuli. CA3 afferents known to be active in response to the auditory stimuli from the medial septal nucleus, entorhinal cortex and dentate gyrus were also simulated. P50 sensory gating compared the network's response to a conditioning stimulus with the network's response to a test stimulus 0.5 seconds later Several mechanisms for P50 sensory gating were explored and simulation results were compared with experimental data recorded from rats and human subjects. Results showed a defect in dopaminergic; neuronal transmission could result in an increase in noise associated with the P50 evoked response. This reduction in the signal-to-noise ratio resulted in a reduction in the amplitude of the P50 auditory evoked potential. A second mechanism, modeled independently, showed that nicotinic cholinergic neuronal transmission from the septum to the hippocampus, while directly modulating P50 sensory gating, also indirectly modulates gating by activating presynaptic GABA(B) receptors which suppresses the test response and enhances P50 sensory gating.
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Details
- Title
- Sensory gating in a computer model of the hippocampus
- Creators
- K A MoxonG A GerhardtL E Adler
- Contributors
- P Calabrese (Editor)A Neugebauer (Editor)
- Publication Details
- MEMORY AND EMOTION, v 12
- Series
- SERIES ON BIOPHYSICS AND BIOCYBERNETICS
- Publisher
- World Scientific
- Number of pages
- 25
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000181288800013
- Other Identifier
- 991019168701004721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neurosciences
- Psychology