Conference proceeding
Surface modification of PLGA microspheres for targeting
Proceedings of the IEEE 28th Annual Northeast Bioengineering Conference (IEEE Cat. No.02CH37342), v 2002-, pp 225-226
2002
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
RGD peptide was conjugated to hollow microspheres to develop PLGA ultrasound contrast agents that enhance ultrasound imaging. The microcapsules were coated with an RGD peptide that targets integrins specific to angiogenesis, /spl alpha/v/spl beta/3 and /spl alpha/v/spl beta/5. The microcapsules were then bound to rat neuroblastoma cells in vitro within 6 hours. The RGD peptide modified microcapsules makes them ideal candidates for targeted therapeutic imaging and drug delivery vehicles.
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Details
- Title
- Surface modification of PLGA microspheres for targeting
- Creators
- J.D Lathia - Drexel UniversityD El-Sherif - Drexel UniversityN.O Dhoot - Drexel UniversityM.A Wheatley - Drexel University
- Publication Details
- Proceedings of the IEEE 28th Annual Northeast Bioengineering Conference (IEEE Cat. No.02CH37342), v 2002-, pp 225-226
- Publisher
- IEEE
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000175970000113
- Other Identifier
- 991019169587304721
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- Web of Science research areas
- Engineering, Biomedical