Conference proceeding
The Effect of Viscosity and Red Blood Cell Aggregation on NO Concentration in the Microcirculation
2015 INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING AND LIFE SCIENCE (BELS 2015)
01 Jan 2015
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The purpose of this study was to investigate the potential effect of viscosity and red blood cell aggregation on nitric oxide (NO) concentration and distribution in the microcirculation. A 3-D multi-physics model was established in COMSOL Multi-physics to simulate NO concentration and distribution in the micro vessel. The non-uniform viscosity was calculated according to both the assumption of linear decline and step decline of hematocrit in the plasma layer. Simulation results show that NO concentration calculated using the step change in the hematocrit model is higher than that using the linear change. Compared with the uniform viscosity model, NO concentration using non-uniform viscosity was a little low both in the linear and the step models. In conclusion, red blood cell aggregation and viscosity may affect nitric oxide distribution in the micro vasculature.
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Details
- Title
- The Effect of Viscosity and Red Blood Cell Aggregation on NO Concentration in the Microcirculation
- Creators
- Hui-Ting Qiao - Beihang Univ, Sch Biol Sci & Med Engn, Minist Educ, Key Lab Biomech & Mechanobiol, Beijing 100191, Peoples R ChinaHong-Jun Zhao - Beihang Univ, Sch Biol Sci & Med Engn, Minist Educ, Key Lab Biomech & Mechanobiol, Beijing 100191, Peoples R ChinaDov Jaron - Drexel UniversityDEStech
- Publication Details
- 2015 INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING AND LIFE SCIENCE (BELS 2015)
- Conference
- 2015 INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING AND LIFE SCIENCE (BELS 2015)
- Publisher
- Destech Publications, Inc
- Number of pages
- 6
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; [Retired Faculty]
- Identifiers
- 991019170443304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical