Conference proceeding
The role of intracellular calcium in axonal injury
The Institute of Electrical and Electronics Engineers, Inc. (IEEE) Conference Proceedings, 1
01 Apr 2014
Abstract
Conference Title: 2014 40th Annual Northeast Bioengineering Conference (NEBEC) Conference Start Date: 2014, April 25 Conference End Date: 2014, April 27 Conference Location: Boston, MA, USA Increased levels of axonal calcium have been found after Traumatic Brain injury. Calcium can enter the cell from an extracellular source or be released from intracellular stores. Here, we investigate the importance of intracellular calcium in axonal pathology by chelating intracellular calcium and isolating components of the injury pathway such as membrane damage, calcium influx, mitochondrial injury, and increased oxidative stress. The findings were that chelating intracellular calcium with BAPTA-AM was neuroprotective after increasing membrane permeability with melittin, damaging mitochondria with CCCP, and increasing oxidative stress with TbHp. Chelating intracellular calcium was not neuroprotective after injuring cells by selectively increasing axonal calcium with A23187.
Metrics
14 Record Views
Details
- Title
- The role of intracellular calcium in axonal injury
- Creators
- R M DastgheybK A BarbeeG Gallo
- Publication Details
- The Institute of Electrical and Electronics Engineers, Inc. (IEEE) Conference Proceedings, 1
- Publisher
- The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Identifiers
- 991019170345604721