Conference proceeding
Towards a Method for Peripheral Nervous System Axonal Stiffness Measurements with MEMS-based Microgrippers
Conference Proceedings. 2nd International IEEE EMBS Conference on Neural Engineering, 2005, v 2005, pp 403-405
2005
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Abstract
We present a novel method for measuring axonal axial stiffness in genetically and metabolically challenged peripheral nerve axons using MEMS-based microgrippers. Using microgrippers with an out of plane stiffness of 122 Newtons/meter, we propose to apply up to 1830 muNewtons of force on axons growing in 50 ng/ml 7s nerve growth factor (NGF) for 4-6 days, then replated on untreated 60 mm tissue culture dishes in 7s NGF media at a strain rate of ~0.01s -1 . From this we propose to determine the relative stiffness and growth contributions of both the actin cytoskeleton and the microtubule-dynenin-kinesin cytoskeleton components
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Details
- Title
- Towards a Method for Peripheral Nervous System Axonal Stiffness Measurements with MEMS-based Microgrippers
- Creators
- B.E Layton - Drexel UniversityK.B Allen - Drexel UniversityK.A Myers - Drexel UniversityM.D Stokes - Drexel UniversityP.W Baas - Drexel UniversityIEEE
- Publication Details
- Conference Proceedings. 2nd International IEEE EMBS Conference on Neural Engineering, 2005, v 2005, pp 403-405
- Publisher
- IEEE
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- Accelerated Career Entry Bachelor of Science in Nursing (BSN); Neurobiology and Anatomy
- Web of Science ID
- WOS:000229610400109
- Scopus ID
- 2-s2.0-33744499941
- Other Identifier
- 991019170578804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Computer Science, Artificial Intelligence
- Computer Science, Interdisciplinary Applications
- Engineering, Biomedical