Conference proceeding
Ultrasound contrast agents targeted to malignancies: optimizing cellular attachment
Proceedings of the IEEE 31st Annual Northeast Bioengineering Conference, 2005
2005
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Hollow poly (lactic acid) (PLA) microcapsules were modified with Arg-Gly-Asp (RGD) peptide to create a targeted contrast agent (CA) that enhances ultrasound imaging. The RGD peptide targets cell-surface receptors (integrins /spl alpha//sub v//spl beta//sub 3/ and /spl alpha//sub v//spl beta//sub 5/) which are overexpressed in cancer and angiogenesis. The influence of RGD surface density and RGD spacer length were evaluated for their contribution to CA attachment to human breast cancer cells. The CA performance was dependent on both the RGD surface density and glycine spacer length and therefore should be considered in the design of a site-targeted CA. The optimized RGD peptide modified microcapsules are ideal candidates for targeted diagnostic imaging and for drug delivery.
Metrics
7 Record Views
Details
- Title
- Ultrasound contrast agents targeted to malignancies: optimizing cellular attachment
- Creators
- K Oum - Thomas Jefferson UniversityJ Vega - Thomas Jefferson UniversityL Leodore - Thomas Jefferson UniversityF ForsbergJ.B LiuD MertonM.A WheatleyIEEE
- Publication Details
- Proceedings of the IEEE 31st Annual Northeast Bioengineering Conference, 2005
- Conference
- IEEE 31st Annual Northeast Bioengineering Conference, 2005, 31st
- Publisher
- IEEE
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000230459300092
- Other Identifier
- 991019170472004721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Engineering, Biomedical