Conference proceeding
Ultrasound microbubble targeted gemcitabine delivery for pancreatic cancer treatment
The Institute of Electrical and Electronics Engineers, Inc. (IEEE) Conference Proceedings
01 Jan 2017
Abstract
Conference Title: 2017 IEEE International Ultrasonics Symposium (IUS) Conference Start Date: 2017, Sept. 6 Conference End Date: 2017, Sept. 9 Conference Location: Washington, DC, USA Pancreatic ductal adenocarcinoma (PDA) is one of the most prevalent types of cancer. Studies have shown that PDA treatment with IV administration of gemcitabine (GEM) is inhibited by excessive interstitium and connective tissue (stroma) surrounding the tumor. Ultrasound (US) irradiation combined with drug-loaded polylactic acid (PLA) microbubble contrast agents (MB) may circumvent this through targeted delivery of GEM and increased permeability of the tumor stroma, while also lodging GEM-loaded fragments into the tumor tissue for sustained release. Thus, the objective of this study was to encapsulate GEM within the shell of PLA MBs and evaluate their treatment efficacy in an in vivo pancreatic cancer mouse model.
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Details
- Title
- Ultrasound microbubble targeted gemcitabine delivery for pancreatic cancer treatment
- Creators
- Lauren JablonowskiJohn EisenbreyDavid BrownMaria StanczakJi-Bin LiuJingzhi LiFlemming ForsbergMargaret Wheatley
- Publication Details
- The Institute of Electrical and Electronics Engineers, Inc. (IEEE) Conference Proceedings
- Publisher
- The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Scopus ID
- 2-s2.0-85039425928
- Other Identifier
- 991019170592904721