Conference proceeding
Utilizing bioinformatics approaches for identifying binding sites in the Drosophila genome for a developmentally important transcription factor protein
Proceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology, v 3, pp 2186-2187 vol.3
2002
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Regulation of gene expression, at the transcription level, in eukaryotes is largely dependent on regulatory proteins called transcription factors. Transcription factors bind to highly specific, short nucleotide sequences on the DNA and regulate transcription by facilitating or inhibiting the binding of RNA polymerase II, the enzyme that catalyzes transcription of eukaryote genes. We are using computational tools that use inherent pattern-searching algorithms to identify binding sites for the Stripe protein, an important transcription factor in Drosophila development. The binding sites for Stripe are expected to lie close to genes that are known to be regulated by this transcription factor. Identifying the locations of these binding sites can be useful in determining the biological significance of these sites through further functional analyses.
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Details
- Title
- Utilizing bioinformatics approaches for identifying binding sites in the Drosophila genome for a developmentally important transcription factor protein
- Creators
- H.B Patel - Drexel UniversityJ Lee
- Publication Details
- Proceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology, v 3, pp 2186-2187 vol.3
- Publisher
- IEEE
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- Decision Sciences (and Management Information Systems)
- Web of Science ID
- WOS:000180194801072
- Other Identifier
- 991019168067104721
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- Web of Science research areas
- Computer Science, Artificial Intelligence
- Engineering, Biomedical
- Instruments & Instrumentation
- Radiology, Nuclear Medicine & Medical Imaging