Conference proceeding
WHAT'S IN A DEFINITION? A SIMULATION FRAMEWORK FOR MODELING SEPSIS INTERVENTIONS USING ELECTRONIC HEALTH RECORDS
The Institute of Electrical and Electronics Engineers, Inc. (IEEE) Conference Proceedings, pp 2483-2494
01 Jan 2018
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Conference Title: 2018 Winter Simulation Conference (WSC) Conference Start Date: 2018, Dec. 9 Conference End Date: 2018, Dec. 12 Conference Location: Gothenburg, Sweden Sepsis, the body’s inflammatory response to infection, is a serious complication and leading cause of in-hospital mortality. Timely intervention is both difficult and critical since sepsis can rapidly worsen to organ dysfunction and septic shock. However, the lack of a gold-standard definition renders the lines between these transitions unclear, complicating medical decision-making. Using electronic health records, we build a simulation framework to study the evolution of dynamic physiological and cellular responses to therapeutic interventions in septic patients. Since sepsis trajectories can manifest differently depending on patient characteristics, we incorporate patient heterogeneity through comorbidity, age, race, and gender. Under therapeutic interventions recommended by the Centers for Medicare and Medicaid Services (CMS), we illustrate the framework on patient trajectories using the CMS criteria for sepsis definition. The framework is designed to support the comparison and quantification of the impact of clinical definitions and recommended interventions on the timely identification of sepsis states.
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Details
- Title
- WHAT'S IN A DEFINITION? A SIMULATION FRAMEWORK FOR MODELING SEPSIS INTERVENTIONS USING ELECTRONIC HEALTH RECORDS
- Creators
- Nisha Nataraj - North Carolina State UniversityJulie S Ivy - North Carolina State UniversityJeanne Huddleston - Mayo ClinicRyan Arnold - Drexel UniversityMuge Capan - Drexel University
- Publication Details
- The Institute of Electrical and Electronics Engineers, Inc. (IEEE) Conference Proceedings, pp 2483-2494
- Series
- Winter Simulation Conference Proceedings
- Publisher
- The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
- Number of pages
- 12
- Grant note
- 1522106; 1522107; 1522072 / National Science Foundation Smart & Connected Health Awards
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- Decision Sciences (and Management Information Systems)
- Web of Science ID
- WOS:000461414102059
- Scopus ID
- 2-s2.0-85062616903
- Other Identifier
- 991019170116204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Computer Science, Theory & Methods