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Code from: Sensory feedback and central neuronal interactions in mouse locomotion
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Code from: Sensory feedback and central neuronal interactions in mouse locomotion

Yaroslav Molkov, Guoning Yu, Jessica Ausborn, Julien Bouvier, Simon M. Danner and Ilya A. Rybak
13 Feb 2024
DOI: https://doi.org/10.5061/dryad.q83bk3jqj
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https://doi.org/10.5061/dryad.q83bk3jqjView
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Abstract

FOS: Biological sciences locomotion Mathematical modeling sensory feedback spinal circuits
Locomotion is a complex process involving specific interactions between the central neural controller and the mechanical components of the system. The basic rhythmic activity generated by locomotor circuits in the spinal cord defines rhythmic limb movements and their central coordination. The operation of these circuits is modulated by sensory feedback from the limbs providing information about the state of the limbs and the body. However, the specific role and contribution of central interactions and sensory feedback in the control of locomotor gait and posture remain poorly understood. We use biomechanical data on quadrupedal locomotion in mice and recent findings on the organization of neural interactions within the spinal locomotor circuitry to create a tractable mathematical model of mouse locomotion. The model includes feedback signals characterizing the load and extension of each limb as well as postural stability. We investigate several model versions and compare their behavior to existing experimental data. Our results highlight specific roles of sensory feedback and some central propriospinal interactions between circuits controlling fore and hind limbs for speed-dependent gait expression. Our models suggest that postural imbalance feedback may be critically involved in the control of swing-to-stance transitions in each limb and the stabilization of walking direction.

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