Dataset
Lipid Acyl Chain-Driven α-Synuclein Fibril Polymorphisms and Neuronal Pathologies
19 Aug 2026
Abstract
Solid-state NMR spectra and microscopy images associated with the following publication:
Y. Baek, A. Alim, Y. Dong, T. Olabi, J. Paek, and M. Lee, “Lipid Acyl Chain-Driven α-Synuclein Fibril Polymorphisms and Neuronal Pathologies,” ACS Chemical Neuroscience 17 (7), 1286–1302 (2026). https://doi.org/10.1021/acschemneuro.5c00730.
lipid free_Aged_Neuron_asyn ssNMR:
Agedmem_2DCC.ucsf: 2D CC ssNMR spectra of a-syn fibrils formed in the presence of Aged mimetic neuronal membranes
Agedmem_2DNC.ucsf: 2D NC ssNMR spectra of a-syn fibrils formed in the presence of Aged mimetic neuronal membrane
Neuronmem_2DCC.ucsf: 2D CC ssNMR spectra of a-syn fibrils formed in the presence of normal mimetic neuronal membranes
Neuronmem_2DNC.ucsf: 2D NC ssNMR spectra of a-syn fibrils formed in the presence of normal mimetic neuronal membrane
lipid_free_2DCC.ucsf: 2D CC ssNMR spectra of a-syn fibrils formed without lipids
lipid_free_2DNC.ucsf: 2D NC ssNMR spectra of a-syn fibrils formed without lipids
Microscope images:
NF-kB: nuclear translocation of NF-κB
α-syn aggregation: Immunofluorescence micrographs showing differential formation of intraneuronal α-syn aggregates in response to structurally distinct α-syn PFFs and lipid conditions.
pSer 129: Immunostaining of α-syn phosphorylated at serine 129
Supporting information: Differentiation of neuroblastoma cells into dopaminergic neurons
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Details
- Title
- Lipid Acyl Chain-Driven α-Synuclein Fibril Polymorphisms and Neuronal Pathologies
- Creators
- Yoongyeong BaekAnika Alim - Binghamton UniversityYanheng Dong - Binghamton UniversityTarek Olabi - Drexel UniversityJungwook Paek - Binghamton UniversityMyungwoon Lee
- Publisher
- Mendeley Data
- Grant note
- National Institutes of Health (https://ror.org/01cwqze88)
- Resource Type
- Dataset
- Language
- English
- Academic Unit
- Biology; Chemistry
- Other Identifier
- 991022203473804721