Dissertation
A systems biology approach to identify molecular determinants of resistance in breast cancer
Doctor of Philosophy (Ph.D.), Drexel University
Nov 2013
DOI:
https://doi.org/10.17918/etd-7181
Abstract
De novo and acquired resistance to anti-estrogen therapy and aromatase inhibitors remains a challenge in the treatment of estrogen-receptor positive breast cancer. We employed a systems biology approach to identify survival determinants of estrogen independent breast cancer cells with varying sensitivities to hormonal therapeutics. An estrogen receptor-centered network was developed using bioinformatics databases to probe, with a network-targeted 631-element siRNA library, for essential genes involved in the proliferation and survival of estrogen independent breast cancer cells. We identified a unique subset of 25 genes that are essential for the proliferation of estrogen independent breast cancer cells, 15 of which also promote apoptosis.
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Details
- Title
- A systems biology approach to identify molecular determinants of resistance in breast cancer
- Creators
- Rochelle Elizabeth Nasto - DU
- Contributors
- Uri Hershberg (Advisor) - Drexel University (1970-)
- Awarding Institution
- Drexel University
- Degree Awarded
- Doctor of Philosophy (Ph.D.)
- Publisher
- Drexel University; Philadelphia, Pennsylvania
- Number of pages
- xv, 135 pages
- Resource Type
- Dissertation
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems (1997-2026); Drexel University
- Other Identifier
- 7181; 991014632231704721