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Dissertation
A study of pulsatile flows with non-Newtonian viscosity of blood in large arteries
Doctor of Philosophy (Ph.D.), Drexel University
Dec 1992
DOI:
https://doi.org/10.17918/00000468
Abstract
The current study offers a fundamental investigation of the effect of hemodynamics on lesion formation in specific arterial configurations in both man and animals. The objective of this investigation is to determine the changes in the flow parameters that occur in the curved, stenosed, mildly tapered, and branched femoral arterial geometries, in order to understand the generation and progression of site-specific atherosclerosis from a hydrodynamic point of view. For diseased vessels with various degrees of atherosclerosis, and for arteries with complex geometries, the effect of the non-Newtonian viscosity of blood on hemodynamics can be much more complicated than in a vessel without disease. Furthermore, the complexity of the flow increases as the flow itself becomes pulsatile in nature. Depending on the location and the nature of pulsatility, the instantaneous shear rate over a cardiac cycle oscillates from negative values to positive values at a magnitude of approximately several hundreds of reciprocal seconds. Thus, in comparison to a straight and smooth vessel, an arterial vessel of complex geometry experiences a vastly different viscosity and shear rate, leading to a shift and increase in the magnitude of oscillating shear stress along the arterial wall. Because specific sites have been identified as prone to blockage and thus to the development of stenosis, it has become important to know the behavior of fluid flow through these sites. This study also aims to determine what happens to blood flow once a blockage develops. The ultimate objective of the present study is to discover whether or not an alteration in flow conditions, i.e., pulsatility or fluid parameters, which may be achieved by pharmaceutical, chemical, or mechanical means, can help to reduce the risk of arterial disease, e.g., heart attack and strokes. Furthermore, numerically-obtained flow results may be compared and used to improve magnetic resonance image (MRI) signals, which are often exaggerated due to signal loss near the stenosed region or arterial sites that have complex geometries, i.e., bends, bifurcations, and branches. Thus, this research also has a potential application from the medical diagnostic point of view.
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Details
- Title
- A study of pulsatile flows with non-Newtonian viscosity of blood in large arteries
- Creators
- Rupak Kumar Banerjee
- Contributors
- Young I. Cho (Advisor)
- Awarding Institution
- Drexel University
- Degree Awarded
- Doctor of Philosophy (Ph.D.)
- Publisher
- Drexel University; Philadelphia, Pennsylvania
- Number of pages
- xv, 207 pages
- Resource Type
- Dissertation
- Language
- English
- Academic Unit
- College of Engineering (1970-2026); Mechanical Engineering (and Mechanics) [Historical]; Drexel University
- Other Identifier
- 991014970194004721