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Dissertation
A study of the biological and mechanical interface between a swelling copolymeric anchor and bone
Doctor of Philosophy (Ph.D.), Drexel University
1998
DOI:
https://doi.org/10.17918/00000827
Abstract
A new family of polymeric swelling-type materials has recently been developed for suture anchor applications. By absorbing body fluids and, thereby swelling small amounts, the materials are capable of achieving self-fixation to bone by an expansion-fit mechanism. The interface characteristics of these materials, including their in vitro and in vivo pull-out strength in rabbit cancellous bone, were evaluated. Additionally, SEM/EDX analyses were performed on selected retrieved samples (after pull-out) in order to determine the effect of constrained swelling on the structural integrity of the implant, as well as the effect of swelling on bony ingrowth. Further, preliminary biocompatibility and degradation studies were conducted. Results indicate that the new family of dynamic implants has potential in suture anchor applications, particularly in applications requiring fixation to cancellous or osteoporotic bone. Peak pull-out loads of up to 240 Newtons (shear strengths of up to 4.1 MPa) were obtained in rabbit cancellous, bone. The swelling implants exhibited better fixation strength in comparison to non-swelling implants, and tended to induce bone deposition at the bone-implant interface.
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Details
- Title
- A study of the biological and mechanical interface between a swelling copolymeric anchor and bone
- Creators
- Gina Marie Gualtieri
- Contributors
- Sorin Siegler (Advisor)Surya Kalidindi (Advisor)
- Awarding Institution
- Drexel University
- Degree Awarded
- Doctor of Philosophy (Ph.D.)
- Publisher
- Drexel University; Philadelphia, Pennsylvania
- Number of pages
- xii, 143 pages
- Resource Type
- Dissertation
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems (1997-2026); Drexel University
- Other Identifier
- 991014970208404721