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An examination of the association between sleep and neurocognitive performance in relapsing-remitting multiple sclerosis
Dissertation   Open access

An examination of the association between sleep and neurocognitive performance in relapsing-remitting multiple sclerosis

Jessica A. Zamzow
Doctor of Philosophy (Ph.D.), Drexel University
Apr 2016
DOI:
https://doi.org/10.17918/etd-6800
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Abstract

Sleep Multiple Sclerosis, Relapsing-Remitting Psychology
Individuals with MS experience a high rate of sleep disorder symptoms and a high frequency of cognitive deficits. Both sleep disturbance and cognitive impairment can have a profound impact on perceived quality of life and functional living. While it is well established that sufficient sleep quality and quantity are necessary for optimal cognitive performance in healthy adults, the relationship between sleep and cognitive function has been largely understudied in MS. The present study is an examination of the association between sleep and cognitive function for individuals with MS through the use of objective and subjective measures of sleep and neurocognitive function. Fifty participants with relapsing-remitting MS completed two weeks of standardized sleep diary and wore actigraphy for fourteen consecutive days. Participants then completed a two-hour testing session comprised of neurocognitive measures and questionnaires. Results indicated that sleep duration and sleep efficiency did not predict performance on tests of attention, vigilance, working memory, processing speed, inhibitory working memory, processing speed, or inhibitory control. Symptoms of all sleep disorders (i.e., insomnia, sleep apnea, and RLS/PLMD) were associated poorer cognitive function in individuals with MS.

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