Desmoplakin gene mutation Amish community Arrhythmogenic cardiomyopathy
Genetically isolated Amish populations often have an increased prevalence of genetic abnormalities. Specifically in the Delaware Amish, there is an increased incidence of the Desmoplakin (DSP) gene mutation, which has been associated with arrhythmogenic cardiomyopathy and sudden cardiac death. Despite clinical exposure to Amish patients, anesthesia providers may lack awareness of these population-specific genetic risks. This quality improvement project utilized a PICOT framework to evaluate anesthesia providers and nurse anesthesia students practicing in Delaware who received a targeted educational intervention on DSP-associated cardiac risk in the Amish population. A pre-post design assessed changes in knowledge and self-reported confidence immediately before and after the intervention. Nonparametric analysis using the Wilcoxon signed-rank test demonstrated a statistically significant increase in confidence (Z = -4.888, p < .001), while the McNemar test revealed significant improvements in knowledge-based responses (p < .05). Overall knowledge scores also improved significantly (Z = -4.878, p < .001). These findings support the effectiveness of targeted educational interventions in improving anesthesia provider knowledge and confidence regarding DSP-related risk, with important implications for perioperative assessment, anesthetic management, and patient safety in high-risk Amish populations.
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Details
Title
Anesthetic implications of the DSP gene mutation in the Delaware Amish
Creators
Mary Katherine Troyer
Contributors
Jessica Ann Hessel (DNP Chair) - Drexel University, Nurse Anesthesia
Awarding Institution
Drexel University
Degree Awarded
Doctor of Nursing Practice (D.N.P.)
Publisher
Drexel University
Number of pages
iii, 7-54 pages
Resource Type
Dissertation
Language
English
Academic Unit
Nurse Anesthesia; Nursing (Graduate); College of Nursing and Health Professions; Drexel University