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Dissertation
Cognitive and psychological sequelae of pediatric bone marrow transplantation
Doctor of Philosophy (Ph.D.), Medical College of Pennsylvania and Hahnemann University
May 1999
DOI:
https://doi.org/10.17918/00007660
Abstract
Previous studies suggest that children who undergo bone marrow transplantation may be at risk for intellectual decline, anxiety and/or depression. This study examined the cognitive and psychological sequelae of pediatric bone marrow transplantation (BMT). One hundred and four children with malignant or non-malignant disorders and no previous cranial radiation therapy participated. Survivors were evaluated at four points in time: pre-BMT, one year post, two years post and two and a half to six years post BMT. Sample sizes at each point in time varied from 24 to 35. Cognitive sequelae were assessed using standard IQ tests and parent report of cognitive abilities. Psychological sequelae were assessed using the parent and child report forms of the Achenbach Child Behavior Checklist. The following medical and psychosocial factors were explored as possible contributors to cognitive and/or psychological sequelae: type of pre-transplant conditioning (total body irradiation plus chemotherapy or chemotherapy only), degree of school absence, length of hospitalization, degree of functional impairment and age at BMT. Results indicated no significant change in IQ over time regardless of pre-transplant conditioning. Parents reported significant sequelae in one area, Academic Skills. Regression analysis suggested that degree of school absence was the only significant contributing factor to academic skills deficits. Group means of parent and child report of psychological functioning fell within the normal range. This preliminary study suggests that pediatric bone marrow transplant survivors could benefit from more extensive academic intervention prior to and during school re-entry.
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Details
- Title
- Cognitive and psychological sequelae of pediatric bone marrow transplantation
- Creators
- Valerie Anne Golomb
- Awarding Institution
- Medical College of Pennsylvania and Hahnemann University
- Degree Awarded
- Doctor of Philosophy (Ph.D.)
- Publisher
- Medical College of Pennsylvania and Hahnemann University; Philadelphia, Pennsylvania
- Number of pages
- vi, 131 pages
- Resource Type
- Dissertation
- Language
- English
- Academic Unit
- Medical College of Pennsylvania and Hahnemann University (1993-1996, 1998-2002); Clinical and Health Psychology [Historical]; School of Health Professions (1998-2000)
- Other Identifier
- 991021888866004721