Ultrasonic waves--Therapeutic use Biomedical Engineering Drug Delivery Systems
The goal of this work was to design, develop and fabricate a flat (<10 mm thick), lightweight (<100g), customizable, fully portable and wearable therapeutic ultrasound applicator, operating in the bandwidth 20kHz to 100kHz. This work specifically aimed at optimizing the flexural transducer performance, so the maximum acoustic output could be achieved with minimum excitation voltage, thus facilitating battery-powered operation. Such optimized design combination is not available as the currently used low frequency (<100kHz) ultrasound applicators are bulky, unwieldy and require heavy instrumentation along with the AC power supply as the excitation source. The unique design described makes the applicator clinically relevant and enables its operation at safe, FDA approved acoustic intensities (<100 mW/cm2 ISPTP, Spatial-Peak, Temporal Peak). The design details along with the acoustic characteristics of the flexural transducer implementation that requires only 10-15V battery supplied driving voltage are described in this thesis. The transducer was tested as tether-free, wearable therapeutic unit in successful treatment of chronic venous- and diabetic ulcers in humans; the results of the successful human studies, performed with this applicator are also included.
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Details
Title
Design and optimization of flexural piezoelectric transducer for development of light weight wearable therapeutic ultrasound patch
Creators
Youhan Sunny - DU
Contributors
Peter Andreas Lewin (Advisor) - Drexel University (1970-)
Awarding Institution
Drexel University
Degree Awarded
Doctor of Philosophy (Ph.D.)
Publisher
Drexel University; Philadelphia, Pennsylvania
Number of pages
xiv, 115 pages
Resource Type
Dissertation
Language
English
Academic Unit
School of Biomedical Engineering, Science, and Health Systems (1997-2026); Drexel University