Dissertation
Developing an electrically sensitive ultrasound enhancing agent
Doctor of Philosophy (Ph.D.), Drexel University
Jul 2020
DOI:
https://doi.org/10.17918/00000050
Abstract
In this work, a novel class of ultrasound enhancing agent (UEA) is developed and characterized in vitro and in vivo. This novel class of UEA combines phase change agents (PCAs) and a nested architecture to create a nested PCA (NPCA). PCAs are sub-micron liquid spheres encapsulated by a surfactant coating that acoustically vaporize, becoming echogenic, upon exposure to sufficient ultrasonic energy. Nesting is performed via a double emulsion synthesis that results in the formation of a phospholipid bilayer that encapsulates an internal aqueous phase. The objective of creating an NPCA is to address short comings and clinical limitations of current U.S. Food and Drug Administration (FDA)-approved UEAs.
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Details
- Title
- Developing an electrically sensitive ultrasound enhancing agent
- Creators
- Michael Cimorelli
- Contributors
- Steven P. Wrenn (Advisor)
- Awarding Institution
- Drexel University
- Degree Awarded
- Doctor of Philosophy (Ph.D.)
- Publisher
- Drexel University; Philadelphia, Pennsylvania
- Number of pages
- xxiii, 163 pages
- Resource Type
- Dissertation
- Language
- English
- Academic Unit
- Chemical (and Biological) Engineering (1970-2026); College of Engineering (1970-2026); Drexel University
- Other Identifier
- 991014695248004721