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Dissertation
Development and application of a finite element model for the study of left ventricular mechanics under normal and ischemic conditions
Doctor of Philosophy (Ph.D.), Drexel University
1998
DOI:
https://doi.org/10.17918/00008179
Abstract
Left ventricular (LV) mechanics, or LV stress and strain distribution, is an important determinant of the various characteristics of cardiac physiology and pathology. Numerous analytical and computational models have been developed in the past to study the LV mechanics and to correlate the stress distribution to the normal or pathological condition of the heart. In this research, a new computational model has been developed and applied successfully for studying the stress distribution and deformation of a heart under normal, regionally ischemic, or infarction condition. This finite element based model differs from all previous models in that it not only incorporates the complex LV geometry, anisotropic myocardial material properties, and realistic physiological boundary conditions, but also includes the effects of active fiber contraction force based on MRI strains and large deformation. The results of the study have shown that, under a normal condition the values of stresses in the LV gradually increase from the base to the apex, indicating that the apical region experiences higher stress than that of the basal region. As the heart condition changes from normal to regional ischemia and infarction, the stress values also decrease, particularly in the ischemic or infarcted region. Thus, with this new model, the relationship between the stress distribution and the condition of the heart can be quantitatively established. This significant contribution will definitely assist in the future studies of LV mechanics under both physiological and pathological conditions.
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Details
- Title
- Development and application of a finite element model for the study of left ventricular mechanics under normal and ischemic conditions
- Creators
- Youmin Zhang
- Contributors
- Dov Jaron (Advisor) - Drexel University, Drexel University (1970-)Peter Andreas Lewin (Advisor) - Drexel University, Drexel University (1970-)Tein-Min Tan (Advisor) - Drexel University, Drexel University (1970-)
- Awarding Institution
- Drexel University
- Degree Awarded
- Doctor of Philosophy (Ph.D.)
- Publisher
- Drexel University; Philadelphia, Pennsylvania
- Number of pages
- xvi, 144 pages
- Resource Type
- Dissertation
- Language
- English
- Academic Unit
- College of Engineering (1970-2026); Drexel University
- Other Identifier
- 991021889004604721