Dissertation
Evaluating the local release, systemic transport, and biological significance of cobalt chromium debris in total knee replacement
Doctor of Philosophy (Ph.D.), Drexel University
Sep 2020
DOI:
https://doi.org/10.17918/00000026
Abstract
Total knee arthroplasty (TKA) is one of the most commonly performed orthopedic surgeries during which a tibial tray, either titanium (Ti) or cobalt-chromium (CoCr) alloys, a polyethylene insert, and a cobalt-chromium alloy femoral component are implanted. Sensitivity to metal debris re-emerged as a concern in arthroplasty, with relatively little research focused on metal release in TKA. The overall focus of this work was to describe the potential biological burden of metallic debris from TKA. This dissertation investigated TKA devices, and tissues collected from routine revision and post-mortem TKA retrievals.
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Details
- Title
- Evaluating the local release, systemic transport, and biological significance of cobalt chromium debris in total knee replacement
- Creators
- Christina Marie Arnholt
- Contributors
- Steven M. Kurtz (Advisor)Paul W. Brandt-Rauf (Advisor)
- Awarding Institution
- Drexel University
- Degree Awarded
- Doctor of Philosophy (Ph.D.)
- Publisher
- Drexel University; Philadelphia, Pennsylvania
- Number of pages
- xx, 153 pages
- Resource Type
- Dissertation
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems (1997-2026); Drexel University
- Other Identifier
- 991014695547704721