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Gender, reproductive, and lifestyle risk factors associated with liver disease severity in chronic hepatitis B infection
Dissertation   Open access

Gender, reproductive, and lifestyle risk factors associated with liver disease severity in chronic hepatitis B infection

Jing Sun
Doctor of Philosophy (Ph.D.), Drexel University
Jun 2015
DOI:
https://doi.org/10.17918/etd-6414
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Abstract

Epidemiology
Hepatitis B is a common infectious disease worldwide. It is linked to a series of liver complications such as inflammation, fibrosis, cirrhosis, hepatocellular carcinoma, and liver-related death. It is well-established that males are more likely to develop severe forms of liver disease compared to female chronic hepatitis B (CHB) patients. The goal of this dissertation was to test three hypotheses that could potentially explain the gender difference between male and female liver disease severity in the hepatitis B infected population. The data in this dissertation is derived from the Haimen City cohort, established in 1992-93 in Haimen City, China. The goal of the first paper is to determine whether lifestyle and environmental related exposures could explain the gender differences in liver disease severity in the HBV infected population. The objective of the second paper is to better understand the impact of estrogen exposure by examining the effect of reproductive history on the severity of liver disease in CHB women. The third paper examines HBV viral load change over time among men and women and determines how this change may predict later liver disease.

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