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Dissertation
Interleukin-1[beta] drives prostate cancer cell cooperation in the bone metastatic niche
Doctor of Philosophy (Ph.D.), Drexel University
Aug 2016
DOI:
https://doi.org/10.17918/etd-7175
Abstract
Advanced prostate cancer frequently leads to bone metastasis, a major cause of morbidity and mortality. In this study, we reveal a novel phenomenon in which interleukin-1[beta] derived from one population of disseminated prostate cancer cells conditions the bone microenvironment to enable metastatic colonization by a diverse cohort of prostate cancer cells. We propose that this cooperation among cancer cells demonstrates a functional role for phenotypic heterogeneity in human bone metastasis, which may be clinically exploited for the benefit of patients with metastatic prostate adenocarcinoma.
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Details
- Title
- Interleukin-1[beta] drives prostate cancer cell cooperation in the bone metastatic niche
- Creators
- Kristina S. Shahriari - DU
- Contributors
- Alessandro Fatatis (Advisor) - Drexel University (1970-)
- Awarding Institution
- Drexel University
- Degree Awarded
- Doctor of Philosophy (Ph.D.)
- Publisher
- Drexel University; Philadelphia, Pennsylvania
- Resource Type
- Dissertation
- Language
- English
- Academic Unit
- College of Medicine; Pharmacology and Physiology; Drexel University
- Other Identifier
- 7175; 991014632545004721