Aberrant semantic associative connectivity may be an underlying characteristic of the cognitive and symptom profile of schizophrenia. Words of varying network size (small or large) and connectivity (high or low) were used in lexical decision and cued recall tasks to test the hypothesis that word processing speed and recall in schizophrenia are modulated by increased activation of associative connectivity. Patients with schizophrenia and controls exhibited increased priming and higher probability of recall when words maintained greater levels of associative connectivity; however, controls demonstrated greatest priming and highest recall when network size was small, while patients exhibited increased priming and better recall when network size was large. These results suggest that the behavioral effects of increased associative activation depend on the size of the activated lexical network. Over-activation of associative networks may work to the patient's "advantage" on tests of priming and cued recall when the activated network is large. When the activated network is small, however, over-activation may make appropriate response selection in patients more difficult, potentially taxing attentional resources. Such distinctions have relevance to cognitive models of schizophrenia that attempt to reconcile accounts of increased automatic associate bias with reduction of verbal working memory and context maintenance.
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Details
Title
Lexical network size and connectivity in schizophrenia
Creators
Stephen T. Moelter - DU
Contributors
Douglas L. Chute (Advisor) - Drexel University (1970-)
Awarding Institution
Drexel University
Degree Awarded
Doctor of Philosophy (Ph.D.)
Publisher
Drexel University; Philadelphia, Pennsylvania
Resource Type
Dissertation
Language
English
Academic Unit
Psychology, Sociology, and Anthropology [Historical]; College of Arts and Sciences; Drexel University
Other Identifier
70; 991014632218604721
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