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Dissertation
Non-invasive optical technologies to monitor wound healing
Doctor of Philosophy (Ph.D.), Drexel University
Dec 2007
DOI:
https://doi.org/10.17918/etd-2757
Abstract
Impaired wound healing is one of the most serious complications of diabetes. Lack of quantitative assessment of healing progress makes diabetic wound management a clinical challenge. Optical non-invasive monitoring of wound healing may be of great value in both acute and chronic wounds, especially in assessing treatments to achieve faster wound healing. The goal of my thesis is to implement clinically relevant optical technologies to study the healing process and understand the tissue changes responsible for optical property changes. The hypothesis underlying my thesis research is that tissue oxygenation, as measured by macroscopic optical properties, can be valuable indicators of the state of healing of a wound. The encouraging results obtained with a handheld imaging station, a frequency domain Near InfraRed (NIR) device, and a diffuse reflectance spectroscopy (DRS) device form the basis of my thesis. The multi-filter imaging system, the single source, four-detector NIR instrument with multiple wavelengths along with a commercially available DRS device were used to follow healing progress on a streptozotocin induced diabetic rat animal model. We were able to collect objective wound geometry data due to image registration. Our results demonstrate that there are significant changes in oxygenated hemoglobin, deoxygenated hemoglobin, and tissue scattering during the wound healing process, and that such differences can be correlated with wound histopathology changes. Based on the results, NIR and DRS can be used as valuable tools to assess biological changes including angiogenesis and collagen formation. DRS scattering is identified as a possible valuable new parameter that correlated well with collagen concentration determined via histology. In vitro collagen phantoms verified the strong correlation between collagen concentration and DRS scattering.
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Details
- Title
- Non-invasive optical technologies to monitor wound healing
- Creators
- Linda Chaoqun Zhu - DU
- Contributors
- Elisabeth S. Papazoglou (Advisor) - Drexel University (1970-)
- Awarding Institution
- Drexel University
- Degree Awarded
- Doctor of Philosophy (Ph.D.)
- Publisher
- Drexel University; Philadelphia, Pennsylvania
- Resource Type
- Dissertation
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems (1997-2026); Drexel University
- Other Identifier
- 2757; 991014632076804721