Dissertation
On the binding stress-enhanced sensitivity of (Pb(Mg_[1/3]Nb_[2/3])O₃)_[0.65]-(PbTiO₃)_[0.35] (PMN-PT) piezoelectric plate sensor (PEPS)
Doctor of Philosophy (Ph.D.), Drexel University
Aug 2015
DOI:
https://doi.org/10.17918/etd-6663
Abstract
(Pb(Mg1/3Nb2/3)O3)0.65-(PbTiO3)0.35 (PMN-PT) piezoelectric plate sensor (PEPS) showed enhanced sensitivity in chemical and biological sensing applications which has been attributed to binding-induced crystalline orientation switching in the PMN-PT layer. However, so far there has been no direct demonstration of PEPS crystalline orientation switching upon target-analyte binding. Using biotin and streptavidin binding as a model detection system and by direct X-Ray diffraction observations after analyte binding we have unambiguously demonstrated that switching of the crystalline orientations of the PMN-PT layer indeed occurred. In addition, we have shown that PEPS sensitivity enhancement increased with an increasing transverse electromechanical coupling constant, -k31, of the PMN-PT layer-which is known to correlate with the crystalline orientation switching capability-by increasing the grain size of the PMN-PT layer or by applying a DC bias electric field. Finally, unprecedented high sensitivity of PEPS with high -k31, (i.e., -k31 > 0.3) were illustrated by the aM (10-18 M) sensitivity of in situ DNA hybridization detection without amplification and by the 100 fg/ml (10-13 g/ml) sensitivity of rapid, in situ protein detection in biological fluids such as troponin I detection in serum for early sign of myocardial infarction (heart attack), Her2 detection in serum for cancer treatment and monitoring, Tn antigen and anti-Tn antibody detection in serum for early cancer detection, and Toxins detection in stool for Clostridium difficile infection detection.
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- Title
- On the binding stress-enhanced sensitivity of (Pb(Mg_[1/3]Nb_[2/3])O₃)_[0.65]-(PbTiO₃)_[0.35] (PMN-PT) piezoelectric plate sensor (PEPS)
- Creators
- Wei Wu - DU
- Contributors
- Wei-Heng Shih (Advisor) - Drexel University (1970-)Wan Y. Shih (Advisor) - Drexel University (1970-)
- Awarding Institution
- Drexel University
- Degree Awarded
- Doctor of Philosophy (Ph.D.)
- Publisher
- Drexel University; Philadelphia, Pennsylvania
- Number of pages
- xv, 171 pages
- Resource Type
- Dissertation
- Language
- English
- Academic Unit
- Materials (Science and) Engineering (Metallurgical Engineering) (1970-2026); College of Engineering (1970-2026); Drexel University
- Other Identifier
- 6663; 991014632389604721