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Dissertation
Post-Polymerization Modification of Block Copolymers for Functionalization-Induced Self-Assembly
Doctor of Philosophy (Ph.D.), Drexel University
Sep 2020
DOI:
https://doi.org/10.17918/00000172
Abstract
This thesis is focused on expanding the utility of post-polymerization modification (PPM) and establishing it as a viable route for the synthesis of self-assembled polymeric nanoparticles through three primary research projects. The first project demonstrates Pd-catalyzed, Suzuki-Miyaura cross-coupling (SMC) as a new, versatile method for PPM on well-defined polymers derived from RAFT polymerization. The second project aims to employ SMC as the driving force behind a novel strategy for inducing dynamic self-assembly of block copolymers into nanoparticles through a technique termed "functionalization induced self-assembly" (FISA). The final project of this thesis improves upon the versatility and ease-of-use of FISA by extending it to the base-catalyzed thiol-epoxide "click" reaction as the primary PPM driving in situ self-assembly, thus achieving convenient polymer nanoparticle synthesis under ambient conditions and atmosphere. Keywords: click reaction, nanoparticle, polymer, RAFT, self-assembly, Suzuki
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Details
- Title
- Post-Polymerization Modification of Block Copolymers for Functionalization-Induced Self-Assembly
- Creators
- David H. Howe
- Contributors
- Andrew J. D. Magenau (Advisor)
- Awarding Institution
- Drexel University
- Degree Awarded
- Doctor of Philosophy (Ph.D.)
- Publisher
- Drexel University; Philadelphia, Pennsylvania
- Number of pages
- xxi, 127 pages
- Resource Type
- Dissertation
- Language
- English
- Academic Unit
- Materials Science and Engineering; College of Engineering; Drexel University
- Other Identifier
- 991014695247204721