Files and links (1)
PDFOpen Access (License Unspecified), Open Access
Dissertation
Studies on surfactant purity, chiral composition, and novel surfactant synthesis in chiral electrokinetic chromatography
Doctor of Philosophy (Ph.D.), Drexel University
Oct 2009
DOI:
https://doi.org/10.17918/etd-3162
Abstract
Electrokinetic chromatography (EKC) has been proven to be a useful tool in order to separate charged, neutral, and neutral and/or charged chiral species with short run times, high efficiencies and excellent resolution. EKC differs from capillary zone electrophoresis (CZE) in that a pseudostationary phase (PSP) is employed in order to separate analytes, providing selectivity that is not achievable in CZE. A variety of additives may be used as the PSP. Some examples are surfactants to form micelles, cyclodextrins (CDs), crown ethers, and polymers. In order to achieve chiral separations, a chiral additive or PSP must be utilized. Chromatographic figures of merit (CFOMs) have been evaluated for a variety of PSP formulations, including micelles, solvent-modified (swollen) micelles and microemulsions. The identity and concentration have also been evaluated and compared to previous formulations of PSPs researched within our group. Purity of the commonly used chiral surfactant in our lab, dodecylcarbonyl valine (DDCV), was evaluated under a variety of methods and its effect on CFOMs determined. Finally, a novel chiral surfactant was synthesized and evaluated under micellar electrokinetic chromatography (MEKC) conditions in order to provide an alternative to the chiral surfactant, DDCV.
Metrics
13 File views/ downloads
16 Record Views
Details
- Title
- Studies on surfactant purity, chiral composition, and novel surfactant synthesis in chiral electrokinetic chromatography
- Creators
- Adeline Bajame Kojtari - DU
- Contributors
- Joe Preston Foley (Advisor) - Drexel University (1970-)
- Awarding Institution
- Drexel University
- Degree Awarded
- Doctor of Philosophy (Ph.D.)
- Publisher
- Drexel University; Philadelphia, Pennsylvania
- Resource Type
- Dissertation
- Language
- English
- Academic Unit
- College of Arts and Sciences; Chemistry; Drexel University
- Other Identifier
- 3162; 991014632933804721