Editorial
Catecholamine dysregulation and neurodegenerative disease: From molecular mechanisms to circuit dysfunction
Brain research, v 1702, pp 1-2
01 Jan 2019
PMID: 29778780
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The catecholamine neurotransmitters are classically known as important global modulators of a wide variety of brain functions including attention, learning, memory, and the regulation of mood. Ongoing investigations of neurodegenerative disease states have revealed that diminished levels of these neurotransmitters may be important preclinical biomarkers. A number of genetic studies have implicated polymorphisms in catecholamine neurotransmitters and related enzymes as etiological factors in disease development, while other pharmacological studies demonstrate their important contribution to declining cognitive status in patients with progressive neurodegenerative disorders. Recent progress in stress neurobiology research has developed the findings that psychological stress may have an important influence on the release of proinflammatory cytokines in the brain microenvironment. This inflammatory state is an underlying disease mechanism thought to contribute to the deleterious effects of chronic stress on disease progression in neurodegenerative disease. In this Special Issue, a series of articles highlight key advances in our understanding of how catecholamine dysregulation impacts neurodegenerative processes and the negative reciprocal effects of neurodegeneration on catecholamine neurotransmission anditsbehavioral consequences. [1st paragraph]
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Details
- Title
- Catecholamine dysregulation and neurodegenerative disease: From molecular mechanisms to circuit dysfunction
- Creators
- E. J. Van Bockstaele - Drexel University, Pharmacology and PhysiologyJ. A. Ross - Drexel University
- Publication Details
- Brain research, v 1702, pp 1-2
- Publisher
- Elsevier
- Number of pages
- 2
- Resource Type
- Editorial
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000454370800001
- Scopus ID
- 2-s2.0-85048317079
- Other Identifier
- 991021860807004721
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- Web of Science research areas
- Neurosciences