Editorial
Metabolite regulates differentiation
Science (American Association for the Advancement of Science), v 360(6389), pp 603-604
11 May 2018
PMID: 29748271
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cellular differentiation involves dynamic epigenetic, transcriptional, and metabolic remodeling as cells transition to a new identity. Evidence is mounting that metabolism and gene regulation are intimately linked, with changes in metabolite availability modulating or even triggering gene transcription. One way that metabolites regulate gene expression is as substrates of enzymes that carry out posttranslational modification of transcription factors and histones. Such metabolites likely have distinct biological roles in different compartments of the cell, and in particular within the nucleus (1, 2). Yet, the extent to which the nucleus is a separate metabolic compartment from the cytosol and the mechanisms by which nuclear metabolite levels affect expression of specific genes have remained largely unknown. On page 618 of this issue, Ryu et al. (3) demonstrate that compartmentalized synthesis of the metabolite oxidized nicotinamide adenine dinucleotide (NAD+), regulates adipocyte differentiation, a process that is essential for metabolic health, through transcriptional control.
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Details
- Title
- Metabolite regulates differentiation
- Creators
- Sophie Trefely - Drexel UniversityKathryn E. Wellen - Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania
- Publication Details
- Science (American Association for the Advancement of Science), v 360(6389), pp 603-604
- Publisher
- Amer Assoc Advancement Science
- Number of pages
- 2
- Resource Type
- Editorial
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000431790900022
- Scopus ID
- 2-s2.0-85046638520
- Other Identifier
- 991021893414504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology