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Editorial
Old dogs with new tricks: intra-axonal translation of nuclear proteins
Neural regeneration research, v 10(10), pp 1560-1562
01 Oct 2015
PMID: 26692839
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Many different types of polarized eukaryotic cells have been shown to segregate synthesis for some protein subpopulations to cytoplasmic domains distant from their nucleus. For neurons, these distances can be tens-to-thousands fold more than the diameter of the cell body. Both axons and dendrites make use of this localized protein synthesis to bring autonomy to these far reaches of the cytoplasm (Gomes et al., 2014). This local mRNA translation is often used to mount a rapid response to extracellular stimuli encountered by the distal axon and dendrite. Indeed, activating translation of mRNAs residing locally at the synapse or growth cone brings a much more rapid response than could be achieved by transporting new proteins from the cell body. The neuron likely reaps a cost benefit from this mechanism in terms of energy consumption, since multiple protein copies can be generated from a single mRNA through sequential rounds of translation. Localized protein synthesis could also more effectively position a protein near its site of action or even bring an unanticipated novel function to the protein.
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Details
- Title
- Old dogs with new tricks: intra-axonal translation of nuclear proteins
- Creators
- Jeffery L. Twiss - Drexel UniversityTanuja T. Merianda - Drexel University
- Publication Details
- Neural regeneration research, v 10(10), pp 1560-1562
- Publisher
- MEDKNOW PUBLICATIONS & MEDIA PVT LTD
- Number of pages
- 3
- Grant note
- R01 NS041596 / NINDS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Editorial
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000364260700009
- Scopus ID
- 2-s2.0-84945564298
- Other Identifier
- 991021892011104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology
- Neurosciences