Encyclopedia entry
Magnetically Targeted Endothelial Cells for Prevention of Vascular Restenosis
TechConnect Briefs, Annual TechConnect World Innovation Conference & Expo, 11, pp.67-70
01 Jan 2017
Abstract
The present study assessed the potential of magnetically mediated delivery of endothelial cells (ECs) to inhibit instent stenosis induced by mechanical injury in a rat carotid artery stent angioplasty model. Syngeneic ECs loaded with polymeric magnetic nanoparticles (MNPs) were administered at the distal end of the stented artery using a brief exposure (12 min) to a uniform magnetic field (1.4- kOe). After two months, magnetic localization of ECs demonstrated significant protection from stenosis at the distal part of the stent in the cell therapy group compared to both the proximal part of stent in the cell therapy group and the control (stented, nontreated) group: 1.7-fold (p < 0.001) less reduction in lumen diameter as measured by B-mode and color Doppler ultrasound, 2.3-fold (p < 0.001) less reduction in the ratios of peak systolic velocities as measured by pulsed wave Doppler ultrasound, and 2.1-fold (p < 0.001) attenuation of stenosis as determined through end point morphometric analysis.
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Details
- Title
- Magnetically Targeted Endothelial Cells for Prevention of Vascular Restenosis
- Creators
- Boris PolyakMikhail MedvedNina LazarevaLindsay SteeleTirth PatelAhmad RaiMenahem Y RotenbergKimberly WaskoAndrew R KohutRichard SensenigGennady Friedman
- Publication Details
- TechConnect Briefs, Annual TechConnect World Innovation Conference & Expo, 11, pp.67-70
- Conference
- TechConnect Briefs, Annual TechConnect World Innovation Conference & Expo, 11, 11th
- Publisher
- WTI-Frankfurt-digital GmbH
- Number of pages
- 1
- Resource Type
- Encyclopedia entry
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Surgery; Electrical and Computer Engineering
- Identifiers
- 991019173714404721