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Microtubule Organization in Neurons
Encyclopedia entry   Open access

Microtubule Organization in Neurons

Ankita Patil, Philip L. Yates and Peter W. Baas
Reference Module in Life Sciences
2017
url
https://doi.org/10.1145/2086696.2086727View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze) Open

Abstract

Axon Axonal transport Dendrite Microtubule Microtubule stability Microtubule-associated protein Molecular motor protein Neuron
The neuron is a highly specialized cell whose morphology is thoroughly linked to its function. Microtubules are prominent components of the neuronal cytoskeleton that provide architectural support for axons and dendrites and provide railways to transport cargoes across potentially long distances. Understanding the organization of microtubules in neurons can provide insights into how neuronal structure influences function. Important questions include how microtubules are organized in neurons, how microtubule stability and dynamics are regulated in different specialized neuronal sub-compartments, and how microtubule defects are implicated in nervous system disease.

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