Encyclopedia entry
Neuronal Transport and Spatial Signaling Mechanisms
Encyclopedia of Cell Biology, v 3, pp 230-242
2016
Abstract
Communication in the nervous system requires axonal processes that often traverse long distances to connect neurons to their targets. Injury of axons disrupts this intercellular communication, and neural function can only be fully restored by regeneration of axons with reinnervation of their targets. Neuronal function depends on precise trafficking of macromolecules and organelles along axons, which is driven by motor proteins. Regeneration requires a near complete shift in this trafficking to support growth of the injured axon. This brings a rather daunting task considering that axons can extend for a meter or more in humans. Here, we highlight recent work that has uncovered previously unrecognized means to support growth of axons and provides new insight into the mechanisms needed for regeneration.
Metrics
6 Record Views
3 citations in Scopus
Details
- Title
- Neuronal Transport and Spatial Signaling Mechanisms
- Creators
- Ashley L Kalinski - Drexel UniversityT Hines - University of South CarolinaD S Smith - University of South CarolinaJeffery Twiss - University of South Carolina
- Publication Details
- Encyclopedia of Cell Biology, v 3, pp 230-242
- Publisher
- Elsevier
- Number of pages
- 13
- Resource Type
- Encyclopedia entry
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Scopus ID
- 2-s2.0-85042104642
- Other Identifier
- 991021892010804721