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Protein Recognition in Biology
Encyclopedia entry

Protein Recognition in Biology

Paula McCourt, Joseph Nickels, Tetsuya Ishino and Irwin Chaiken
Handbook of Biosensors and Biochips
27 Oct 2007

Abstract

signal transduction transcriptional regulation intracellular complexes SREBP cleavage activating protein (SCAP) intracellular trafficking sterol regulatory element‐binding proteins (SREBPs) Rvs167 protein phosphorylation cytokine receptor assembly interleukin‐5 receptor activation protein interactions sterol‐sensing domain membrane‐associated complexes SH3 domain ubiquitination BAR domain heterodimer formation antagonist design biomolecular sensing
Protein recognition is pervasive in living systems. Interactions of proteins with each other and with other biomolecules occur in crowded and dynamic environments, ultimately leading to the multimolecular assemblies and networks that are recurrent components underpinning the molecular mechanisms of health and disease. Appreciating the nature and environment of protein interactions can help identify opportunities for molecular sensing in biological systems and guide the conditions needed for biomolecular sensing using biosensors and biochips.

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