Encyclopedia entry
The Septin Cytoskeleton: Assembly and Functions in Intracellular Organization
Encyclopedia of Cell Biology: Volume 1-6, Second Edition, v 3, pp 70-78
01 Jan 2022
Abstract
Septins comprise a network of non-polar filamentous oligomers and polymers, which assemble in a guanine nucleotide-dependent manner. Septins are structurally and functionally integrated into the membrane skeleton, and the cytoplasmic networks of actin filaments and microtubules. The primary function of septins is to control the spatial organization of membrane and cytoplasmic proteins by forming scaffolds and barriers. Thus, septins play key structural and regulatory roles in many of the functions and processes of the eukaryotic cell. Importantly, aberrations in septin expression and function are linked to the pathogenesis of various disease states
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Details
- Title
- The Septin Cytoskeleton: Assembly and Functions in Intracellular Organization
- Creators
- Benjamin P. Robinson - Drexel UniversityLee Dolat - Drexel UniversityElias T. Spiliotis - Drexel University
- Publication Details
- Encyclopedia of Cell Biology: Volume 1-6, Second Edition, v 3, pp 70-78
- Publisher
- Elsevier
- Resource Type
- Encyclopedia entry
- Language
- English
- Academic Unit
- Biology
- Scopus ID
- 2-s2.0-85158984332
- Other Identifier
- 991022237375804721