Thesis
Acoustic characterization of a nested voltage-sensitive ultrasound enhancing agent
Master of Science (M.S.), Drexel University
28 Jun 2019
DOI:
https://doi.org/10.17918/00000253
Abstract
Nesting ultrasound enhancing agents such as microbubbles or emulsions of perfluorocarbons in a phospholipid bilayer has been shown to increase the length of contrast imaging, to decrease the chance of biological effects from inertial cavitation, and to offer the possibility of tuning the bilayer chemistry to create theranostics with broad ranging clinical applications. This work confirms that the non-linear scattering activity of a novel nested phase change ultrasound enhancing agent is dependent on the presence of a low-strength electric field (~1 V/cm). This work discusses experimental acoustic scattering results of perfluorobutane microbubbles, perfluorobutane and perfluoropentane droplets, and perfluoropentane droplet structures nested in phospholipid bilayers in detail, and the influence of the presence of an external electric field while altering the nesting shell's charge and chemistry on the magnitude of key harmonic frequencies in the scattered acoustic responses for a range of transmitted peak negative pressures (0.2 - 4 MPa) at two excitation frequencies (1 & 2.25 MHz).
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Details
- Title
- Acoustic characterization of a nested voltage-sensitive ultrasound enhancing agent
- Creators
- Michael Alexander Flynn
- Contributors
- Steven P. Wrenn (Advisor)
- Awarding Institution
- Drexel University
- Degree Awarded
- Master of Science (M.S.)
- Publisher
- Drexel University; Philadelphia, Pennsylvania
- Number of pages
- x, 61 pages
- Resource Type
- Thesis
- Language
- English
- Academic Unit
- Chemical (and Biological) Engineering (1970-2026); College of Engineering (1970-2026); Drexel University
- Other Identifier
- 991014695545704721