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PDFOpen Access (License Unspecified), Open Access
Thesis
Detection of neointimal neck coverage of saccular intracranial aneurysms via catheterized fiber optic white light spectroscopy
Master of Science (M.S.), Drexel University
Sep 2012
DOI:
https://doi.org/10.17918/etd-4040
Abstract
The use of coil embolization for treatment of intracranial aneurysms has seen a rise in regularity within the last decade. While coil embolization offers a less invasive alternative to clipping with a much lower recovery time, it does not guarantee aneurysm occlusion. The determination of success for coil embolization procedures hinges upon the development of a layer of endothelial tissue across the neck of the aneurysm. Due to the lack of existing medical imaging technology with the capability to detect this tissue, this study investigated the detection of this endothelial tissue using light scattering spectroscopy. The analysis was conducted using spectroscopic phantom tissues as analogues for true endothelial cells. These phantom tissues consisted of an aqueous methylcellulose solution with polystyrene microspheres representing the nuclei of endothelial cells. The results of this study represent a preliminary indication that the detection of endothelial tissue may be possible; however, additional research is necessary to determine conclusively whether or not this analysis method is practical for the detection aneurysm neck coverage.
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Details
- Title
- Detection of neointimal neck coverage of saccular intracranial aneurysms via catheterized fiber optic white light spectroscopy
- Creators
- Daniel James Wanuga - DU
- Contributors
- Timothy P. Kurzweg (Advisor) - Drexel University (1970-)
- Awarding Institution
- Drexel University
- Degree Awarded
- Master of Science (M.S.)
- Publisher
- Drexel University; Philadelphia, Pennsylvania
- Resource Type
- Thesis
- Language
- English
- Academic Unit
- College of Engineering (1970-2026); Electrical (and Computer) Engineering [Historical]; Drexel University
- Other Identifier
- 4040; 991014632514404721