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PDFOpen Access (License Unspecified), Open Access
Thesis
Electrospun cartilage glycosaminoglycans for biomimetic scaffolds
Master of Science (M.S.), Drexel University
May 2012
DOI:
https://doi.org/10.17918/etd-3885
Abstract
Osteoarthritis is a condition through which cartilage is broken down by the human body (1). Osteoarthritis of the knee affects approximately 84.5 million people over the age of 45 in the US alone, or over 27% of the entire population (1). In order to help combat such a debilitating condition, this study investigated electrospinning natural polymers that are found in human cartilage: hyaluronic acid and chondroitin sulfate. Polymer fibers were created using two different solvent systems: aqueous N,N - dimethylformamide and acetic acid. Optimization tests were performed on each sample to attempt to control factors such as fiber diameter and polymer concentration. In order to understand which system would be better for the human body, crosslinking and solubility studies were performed. When attempting to spin, it was discovered that only the solution containing aqueous N,N - dimethylformamide and an excess of HA could be successfully be electrospun and crosslinked.
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Details
- Title
- Electrospun cartilage glycosaminoglycans for biomimetic scaffolds
- Creators
- Sean Michael Dowd - DU
- Contributors
- Caroline L. Schauer (Advisor) - Drexel University (1970-)
- Awarding Institution
- Drexel University
- Degree Awarded
- Master of Science (M.S.)
- Publisher
- Drexel University; Philadelphia, Pennsylvania
- Resource Type
- Thesis
- Language
- English
- Academic Unit
- Materials (Science and) Engineering (Metallurgical Engineering) [Historical]; College of Engineering (1970-2026); Drexel University
- Other Identifier
- 3885; 991014632718904721