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Extending the Glue visualization tool with biological data-types
Thesis   Open access

Extending the Glue visualization tool with biological data-types

Alex Koszycki
Master of Science (M.S.), Drexel University
01 Jun 2015
DOI:
https://doi.org/10.17918/etd-6501
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Abstract

Quantitative research Bioinformatics Biomedical Engineering
Glue is a data visualization tool designed for exploratory analysis that allows users to interactively explore relationships and patterns in large multidimensional datasets. Users can construct scatter plots and histograms, select regions of interest, and have their selections propagated across other visualizations and even across multiple files. This powerful functionality, known as data brushing, is immensely useful in teasing out hidden relationships in large complex datasets. Originally developed for astronomical information, we have subsequently extended its use with common biological data-types and visualizations. This project will present and discuss the addition of features designed for visualizing longitudinal time-series datasets and genetic sequences, both of which are common data-types in biological processes. These features will be illustrated in a research case study investigating how sequence variants of the human immunodeficiency virus type 1 (HIV-1) affect clinical outcomes. The implemented features will be discussed in the context of alternative solutions and broad impact.

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