Thesis
Formamidine synthesis via isocyanide insertion into N-H bonds
Master of Science (M.S.), Drexel University
Jun 2026
DOI:
https://doi.org/10.17918/00011420
Abstract
Isocyanides undergo a facile insertion into activated X-H bonds. Missing from these heteroatom reactions is the insertion of isocyanides into amines promoted by non-metal activators. Described in this thesis is the first insertion of isocyanides into primary and secondary amines using silicon tetrachloride as a non-metal activator to generate formamidines, a valuable functionality for synthesizing pharmaceuticals. In addition, formamidines are widely used as insecticides and acaricides and have been reported to improve the performance of solar cells. The research described in this thesis will describe the development of a new method to make formamidines, the likely reaction mechanism, the reaction scope, and their isolation, characterization, and stability.
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Details
- Title
- Formamidine synthesis via isocyanide insertion into N-H bonds
- Creators
- Albert A. Paredes Rodriguez
- Contributors
- Fraser F. Fleming (Advisor)
- Awarding Institution
- Drexel University
- Degree Awarded
- Master of Science (M.S.)
- Publisher
- Drexel University
- Number of pages
- x, 28 pages
- Resource Type
- Thesis
- Language
- English
- Academic Unit
- College of Arts and Sciences; Chemistry; Drexel University
- Other Identifier
- 991022189371404721