Thesis
Gold nanoparticle decorated carbon nanopipettes for intracellular sers
Master of Science (M.S.), Drexel University
Jun 2013
DOI:
https://doi.org/10.17918/etd-4248
Abstract
Single cell analysis is an increasingly important factor for understanding fundamental cellular functions at the molecular level. As a label-free technique capable of measuring multiple molecules simultaneously, surface enhanced Raman spectroscopy (SERS) is an ideal candidate for miniaturization to the cellular level. Current SERS-active probe designs are limited by their size, fabrication difficulty, or background signal derived from functionalization. In this work, a protocol for batch fabrication of residue-free gold nanoparticle decorated carbon nanopipettes was developed. SERS-activity of the decorated nanopipettes was demonstrated on droplets of 1 mM glycine. The stability of the attached nanoparticles was confirmed in vivo by interrogation of living cells. Moreover, identification of several key factors related to particle growth will provide an avenue for future optimization of particle size and coverage.
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Details
- Title
- Gold nanoparticle decorated carbon nanopipettes for intracellular sers
- Creators
- Travis S. Longenbach - DU
- Contributors
- Yury Gogotsi (Advisor) - Drexel University (1970-)
- Awarding Institution
- Drexel University
- Degree Awarded
- Master of Science (M.S.)
- Publisher
- Drexel University; Philadelphia, Pennsylvania
- Resource Type
- Thesis
- Language
- English
- Academic Unit
- Materials (Science and) Engineering (Metallurgical Engineering) (1970-2026); College of Engineering (1970-2026); Drexel University
- Other Identifier
- 4248; 991014632211004721