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Thesis
Hardware improvement in cold pressor test and Peltier system for measurement of hemodynamic response to pain by fNIR spectroscopy
Master of Science (M.S.), Drexel University
Aug 2012
DOI:
https://doi.org/10.17918/etd-4039
Abstract
Functional Near-Infrared (fNIR) spectroscopy is a relatively new imaging technology which allows a continuous and non-invasive monitoring of changes in cerebral hemodynamics and blood oxygenation. A number of studies have reported changes in the hemodynamic activity in response to experimental pain in human subjects using several imaging modalities, including fMRI and laser Doppler sonography/flowmetry. In our lab (CONQUER CollabOrative, Drexel University) fNIR is employed to study the changes in hemodynamic responses to acute cold pain. The hemodynamic response to different levels of pain has been investigated at our lab by delivering cold noxious stimuli by limb immersion in cold water a.ka. cold pressor test (CPT) and through ceramic plates (Peltier device) respectively. Two configurations of 'far' and 'near' optode spacing were used to investigate both pain-related cortical as well as systemic hemodynamic changes. However, the existing sensor used for capturing the fNIR recording needed some further hardware improvement to eliminate the glitches in smooth experimentation. Moreover, there was a critical need for developing corresponding adapter circuit for the control circuit used for operating the light sources and photo-detectors of the fNIR sensors. Furthermore, optimum parameters to be used for delivering cold noxious stimuli needed to be investigated for the existing peltier device setup. This thesis addresses these hardware designs and development concerns done to achieve better experimentation. Results from tolerance tests using CPT suggest that the systemic change in the blood flow in response to acute episodes of cold painful stimuli can be objectively monitored and assessed through the biological marker measured by fNIR spetroscopy. Results from Peltier study suggest that noxious cold stimuli evoke a less generalized hemodynamic response when compared with CPTs, which is yet detectable with fNIR spectroscopy.
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Details
- Title
- Hardware improvement in cold pressor test and Peltier system for measurement of hemodynamic response to pain by fNIR spectroscopy
- Creators
- Rutvi Vyas - DU
- Contributors
- Kambiz Pourrezaei (Advisor) - Drexel University (1970-)
- Awarding Institution
- Drexel University
- Degree Awarded
- Master of Science (M.S.)
- Publisher
- Drexel University; Philadelphia, Pennsylvania
- Resource Type
- Thesis
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems (1997-2026); Drexel University
- Other Identifier
- 4039; 991014632252204721