Thesis
Long non-coding RNAs in aging
Master of Science (M.S.), Drexel University
31 Aug 2021
DOI:
https://doi.org/10.17918/00000519
Abstract
LncRNAs are an important class of non-coding RNAs that play important regulatory functions, including DNA repair, regulation of gene expression, and as prospective biomarkers for several disorders, including cancer, neuropsychiatric, and cardiac disorders and aging. They interact with various biomolecules to carry out these numerous functions. Aging is an irreversible process that involves the deterioration of normal body functions caused due to several molecular changes. The various contributing factors to aging include reduced telomere functions, DNA damage, epigenetic changes, dysfunction of mitochondria, changes in chromosome structure, and depletion of stem cell pool. As lncRNAs have been associated with the regulation of several biological processes, they have been a subject of interest. This review focuses on the role of lncRNAs in cellular aging.
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Details
- Title
- Long non-coding RNAs in aging
- Creators
- Thuraya Alruwaili
- Contributors
- Srinivas Somarowthu (Advisor) - Drexel University, Biochemistry and Molecular Biology
- Awarding Institution
- Drexel University
- Degree Awarded
- Master of Science (M.S.)
- Publisher
- Drexel University; Philadelphia, Pennsylvania
- Number of pages
- 31 pages
- Resource Type
- Thesis
- Language
- English
- Academic Unit
- College of Medicine; Drexel University
- Other Identifier
- 991015606369704721