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Thesis
Optimal hydrogels for fast and safe delivery of bioactive compounds
Master of Science (M.S.), Drexel University
Dec 2007
DOI:
https://doi.org/10.17918/etd-2529
Abstract
The design of injectable, biocompatible hydrogels encapsulating bioactive substances and exhibiting minimal aerosol formation is an important problem and its optimal solution can lead to more effective delivery vehicles in various applications. The delivery rate from such hydrogels is generally slow if one targets minimal aerosol formation. This thesis explores different biomaterials as potential hydrogels for such applications. The design criteria are good extrusion consistency without phase separation, fast release rate of the encapsulated biomolecule and ability to maintain the functionality of the encapsulated entity. In vitro tests were developed to evaluate the hydrogels synthesized. We were able to develop a gel showing good extrusion consistency and fast release rate of an active virus.
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Details
- Title
- Optimal hydrogels for fast and safe delivery of bioactive compounds
- Creators
- Siddharth B. Gadkari - DU
- Contributors
- Elisabeth S. Papazoglou (Advisor) - Drexel University (1970-)
- Awarding Institution
- Drexel University
- Degree Awarded
- Master of Science (M.S.)
- Publisher
- Drexel University; Philadelphia, Pennsylvania
- Resource Type
- Thesis
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems (1997-2026); Drexel University
- Other Identifier
- 2529; 991014632685404721